The data were derived from a prospectively maintained database repository. Disease recurrence factors, recurrence types, and recurrence-free survival times were subjects of a detailed examination. Surgery was performed on 118 patients presenting with LACC over the course of the study. Adjuvant therapy was given to 41 patients (347%), and 62 (525%) of them subsequently had recurrence. According to multivariable analysis, disease recurrence was observed to be associated with tumor and nodal stages, in addition to the number of lymph nodes retrieved. Among the patient population, 8 (68%) experienced local recurrence; 30 (254%) displayed distant metastases; and 24 (203%) showed peritoneal carcinomatosis. Early recurrence was identified in 27 cases (representing 229%), with peritoneal carcinomatosis being the dominant subtype. The univariate analysis examined the impact of preoperative serum CA 19-9 levels, tumor burden, and lymph node involvement on recurrence-free survival. Among the various factors, only tumor stage maintained its significance in the multivariable model. Our research data implies a correlation between the yield of lymph nodes, the presence and stage of the tumor, and nodal classification and the likelihood of recurrence in patients post-curative resection for LACC.
The online version offers supplementary material that can be found at the URL 101007/s13193-022-01672-x.
An online resource, 101007/s13193-022-01672-x, offers supplementary material related to this document.
Carcinoma rectum management in low- and middle-income countries frequently necessitates diversion colostomy, as a substantial patient population confronts partial intestinal blockages. The objective of this research was to contrast laparoscopic and open methods of fecal diversion in rectal adenocarcinoma cases, implemented as a preparatory step. The terminal objective of our research was the elapsed time until the start of neoadjuvant chemo-radiation therapy. This study retrospectively examined all patients diagnosed with carcinoma of the rectum who underwent a pretreatment fecal diversion procedure between 2012 and 2014. Among the 55 patients who underwent pretreatment diversion colostomy, a laparoscopic procedure was selected in 33 cases and an open procedure was utilized in 22 cases. Compared to the open surgical group (205 days), the laparoscopic group exhibited a substantially reduced time to initiate neoadjuvant therapy (16 days), yielding a statistically significant difference (P=0.031). A laparoscopic diversion colostomy as a pretreatment approach was safely utilized in low- and middle-income nations, demonstrating advantages in faster recovery and early neoadjuvant therapy initiation for patients with locally advanced, partially obstructed rectal cancer.
The condition of trismus involves impaired mouth opening. To effectively evaluate trismus and its treatment results, a multi-faceted, self-administered, trismus-specific tool is essential. From a present perspective, the Gothenburg trismus questionnaire is the only trustworthy metric for assessing trismus severity. Documenting trismus-related problems in a standardized manner, through translation of this questionnaire, provides insight into patient treatment outcome perspectives within diverse populations. To ensure effective application in Telugu-speaking patients within the region, this study aimed to translate the Gothenburg trismus questionnaire-2 (GTQ-2) into Telugu and validate the translation. The GTQ 2 translation was guided by the International Society for Pharmacoeconomics and Outcomes Research's standardized procedure which included (1) forward translation, (2) reconciliation and harmonization, (3) back translation, and (4) cognitive debriefing and subsequent pilot testing. A comprehensive psychometric assessment of the translated version was conducted, encompassing measures of internal consistency, construct validity, known-group validity, and the detection of floor and ceiling effects. The Head and Neck Oncology outpatient clinic study population comprised patients with or without trismus, who were selected for participation. The Mann-Whitney U-test was employed to compare GTQ scores. By using the Pearson correlation coefficient, convergent and divergent validity were examined. Internal consistency was determined via the calculation of Cronbach's alpha coefficient. Mucosal microbiome A translated version of the GTQ 2 questionnaire was completed by 60 participants, subdivided into two equal groups: 30 trismus patients and 30 non-trismus patients. GTQ 2's translation was accomplished without any major difficulties. The translated version's internal consistency is strong (greater than 0.7), confirming its construct validity. Following translation, the instrument successfully categorized individuals according to the presence or absence of trismus, displaying a statistically significant difference (p<0.00005). A newly available Telugu version of the Gothenburg Trismus Questionnaire-2, both valid and reliable, is beneficial to Indian patients.
Supplementing the online version, additional material is available at the website address: 101007/s13193-021-01369-7.
The online document has further resources located at the cited address: 101007/s13193-021-01369-7.
Uterine carcinosarcoma, a rare and rapidly progressing neoplasm with a highly aggressive nature, is unfortunately associated with a poor prognosis. While a relatively rare occurrence comprising just 1-5% of all uterine malignancies, it tragically accounts for 164% of all deaths caused by these malignancies. The Indian subcontinent unfortunately exhibits a considerable lack of available data. This retrospective study was designed to analyze the clinical and pathological characteristics, along with the outcomes, of patients diagnosed with uterine carcinosarcoma at this tertiary care center in the past ten years. A retrospective analysis of uterine carcinosarcoma cases, histologically confirmed, in women treated at a tertiary cancer center in South India, spanning the period from August 2009 to April 2019. Following a review of inpatient and outpatient records, clinicopathological data were collected, and follow-up and survival data were established. Within the span of ten years, twenty cases of uterine carcinosarcoma were identified. A large majority (80%) of the patients were beyond the menopausal stage. The principal presenting symptom for roughly eighty percent of patients was post-menopausal bleeding. A significant proportion of patients, exceeding two-thirds, presented at early stages of disease (stage I, 55%; stage II, 20%). All patients' treatments commenced with a staging laparotomy. Patients with good performance status (85%) were provided with adjuvant concurrent chemoradiotherapy and chemotherapy. A median follow-up period of 40 months revealed 7 surviving patients (35% of the total). Among these, 6 remained disease-free, and 1 experienced a recurrence. Following a 40-month median follow-up period, the event-free survival rate stood at 40%, and the overall survival rate was 485%. Regardless of age, tumor histology (heterologous versus homologous), stage, or depth of myometrial invasion, the outcome did not significantly diverge. Despite its rarity, uterine carcinosarcoma must be distinguished and treated with assertiveness. Surgical procedures are essential in the therapeutic process. While adjuvant chemoradiotherapy and concurrent chemotherapy may positively influence local control and potentially delay tumor relapse, their impact on survival has not been substantial. The search for the optimal adjuvant treatment for this uncommon illness continues, highlighting the urgent requirement for larger, multicenter trials focused on this tumor.
The following case series examined five patients with localized prostate cancer (PCa) who had radiation recurrence and underwent salvage robot-assisted radical prostatectomy (sRARP). Postoperative follow-up, with a median duration of 8 months, was conducted on the patients. Operative time, estimated blood loss, and length of hospital stay, as peri-operative parameters, presented median values of 127 minutes (range 113-158 minutes), 61 milliliters (range 54-111 milliliters), and 9 days (range 8-11 days), respectively. Five patients did not experience the need for conversion to open procedures, blood transfusions, or any rectal/ureteral complications. One in five (20%) patients displayed urinary leakage during the initial cystogram. For a patient experiencing hematuria (20%), transurethral electrocoagulation under spinal anesthesia was undertaken as the treatment. A noteworthy finding was that 40% of the two patients experienced biochemical progression; critically, none passed away due to prostate cancer or any alternative causes during the observation period. Continence was maintained by three of the five patients, which translates to 60%. In cases of radiation-recurrent localized prostate cancer (PCa), sRARP could potentially emerge as a viable surgical approach, yielding satisfactory results.
In India, female breast cancer (BC) holds the distinction of being both the most frequent cancer diagnosis and the most frequent cause of cancer death among women. Stem-cell biotechnology In India, initial presentations of breast cancer cases are predominantly (>70%) advanced BC, with locally advanced breast cancer (LABC) necessitating a multifaceted approach incorporating both systemic and locoregional treatments. With institutional ethics committee approval in place, the one-year-long descriptive hospital-based study was carried out. The investigation comprised 55 patients who successfully met all the criteria stipulated for the study. The data collection process culminated in the aggregation of data into Excel spreadsheets and its subsequent analysis using appropriate statistical tools. A significant portion of the patients, being postmenopausal and multiparous, experienced breast lumps as the most common symptom. find more Baseline characteristics included a mean age of 48 years, a maximum standardized uptake value (SUV) of 92, and a Ki-67 proliferation index of 178%. cT4 and cN2 represented the most frequent pre-NACT tumor and lymph node staging. Invasive ductal carcinoma, the most frequent tumor type, was also characterized by a preponderance of grade 3 tumors. Following neoadjuvant chemotherapy (NACT), 32 patients decided on breast-conserving surgical procedures.